Which street corresponds to the 4E route?

Answer: D — Buffum

Route-number to street alignment is what this item is about. The 4E designation points to a specific east–west corridor on the city’s route map, and Buffum Street is the street that sits on that corridor in the system used here. The other streets listed do not lie on that 4E corridor, so they don’t match the route’s assigned street. That’s why Buffum is the correct match for the 4E route.