Under Regulation (EU) No 181/2011, on what grounds may a bus carrier legally refuse to accept a reservation, issue a ticket, or embark a person with disabilities or reduced mobility (PRM)?

1. Solely in order to comply with applicable safety requirements established by international/EU/national law, or where vehicle design/infrastructure makes boarding or carriage physically impossible
2. Whenever other passengers object to traveling with a disabled person
3. Whenever the journey lasts longer than 1 hour
4. Whenever the bus is painted in commercial company colors